Gastric DLBCL clonal evolution as function of patient age

Irina Iosselevitch, Hilla Tabibian-Keissar, Iris Barshack, Ramit Mehr*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Diffuse large B cell lymphoma (DLBCL) is the most common type of NHL, accounting for about 40% of NHL cases, and is one of the most aggressive lymphomas. DLBCL is widespread in individuals aged more than 50 years old, with a maximum incidence in the seventh decade, but it may also occur in younger patients. DLBCL may occur in any immune system tissue, including those around the gastrointestinal tract, and even in the stomach, though gastric DLBCL has yet to be sufficiently investigated. This study aimed to understand changes in gastric Diffuse Large B cell lymphoma (gastric DLBCL) development with age. Immunoglobulin (Ig) heavy chain variable region genes were amplified from sections of nine preserved biopsies, from patients whose age varied between 25 and 89 years, sequenced and analyzed. We show first that identification of the malignant clone based on the biopsies is much less certain than was previously assumed; and second that, contrary to expectations, the repertoire of gastric B cell clones is more diverse among the elderly DLBCL patients than among the young.

Original languageEnglish
Article number957170
JournalFrontiers in Immunology
StatePublished - 29 Aug 2022


  • B lymphocytes
  • Immunoglobulin (Ig)
  • aging
  • antigen receptor repertoire
  • gastric diffuse large B cell lymphoma (DLBCL)
  • high-throughput sequencing (HTS)
  • lineage trees
  • somatic hypermutation


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