Gait Measures as Predictors of Poststroke Cognitive Function: Evidence from the TABASCO Study

Einor Ben Assayag, Shani Shenhar-Tsarfaty, Amos D. Korczyn, Efrat Kliper, Hen Hallevi, Ludmila Shopin, Eitan Auriel, Nir Giladi, Anat Mike, Anat Halevy, Aner Weiss, Anat Mirelman, Natan M. Bornstein*, Jeffrey M. Hausdorff

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Background and Purpose-Patients with stroke are at risk for developing cognitive impairment. We tested whether the assessment of balance and gait can enhance the prediction of long-term cognitive outcome in stroke survivors. Methods-Participants were patients with first-ever, mild-moderate ischemic stroke or transient ischemic attack from the Tel Aviv Brain Acute Stroke Cohort (TABASCO) study, a large prospective cohort study, who underwent 3-T MRI and were followed for ≥2 years using neurological, neuropsychological, and mobility examinations 6, 12, and 24 months after the index event. Results-Data were available for 298 patients (age: 66.7±9.6 years). Forty-six participants (15.4%) developed cognitive decline (CD) over the 2 years of follow-up. The CD group and cognitively intact group did not differ in their neurological deficits or in their infarct volume or location. Nonetheless, 6 months after stroke, the Timed Up and Go test took longer in those who later developed CD (P<0.001). Additionally, the CD group also had lower Berg Balance Scale scores (P<0.001), slower gait (P<0.001), and fewer correct answers during dual-task walking (P=0.006). Separate analyses of the patients with transient ischemic attack revealed similar results. Multivariate regression analysis showed that Timed Up and Go times >12 s at 6 months after stroke/transient ischemic attack was a significant independent risk marker of CD 24 months after stroke (odds ratio=6.07, 95% confidence interval: 1.36-27.15). Conclusions-These results suggest that measures of balance and gait are significant risk markers of cognitive status 2 years after stroke. Relatively simple, performance-based tests of mobility may enhance the identification of stroke/transient ischemic attack survivors who have an increased risk of developing CD.

Original languageEnglish
Pages (from-to)1077-1083
Number of pages7
Issue number4
StatePublished - 20 Apr 2015


FundersFunder number
American Federation for Aging ResearchRAG11482


    • gait
    • mild cognitive impairment
    • stroke


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