TY - JOUR
T1 - Gait dynamics in Parkinson's disease
T2 - Common and distinct behavior among stride length, gait variability, and fractal-like scaling
AU - Hausdorff, Jeffrey M.
N1 - Funding Information:
The author is indebted to the patients and staff of the Movement Disorders Unit of the Tel Aviv Sourasky Medical Center for their input and assistance, to Professor Nir Giladi, Professor Ary Goldberger, and Professor C. K. Peng for their invaluable collaborative efforts, to Talia Herman and Leor Gruendlinger for crucial assistance, and to many others who have contributed to the work that is the basis of this review. This work was supported in part by NIH (Grant Nos. AG-14100, RR-13622, HD-39838, and AG-08812), by the European Union Sixth Framework Program, FET (Contract No. 018474-2), Dynamic Analysis of Physiological Networks (DAPHNet), SENSACTION-AAL, and by the National Parkinson Foundation.
PY - 2009
Y1 - 2009
N2 - Parkinson's disease (PD) is a common, debilitating neurodegenerative disease. Gait disturbances are a frequent cause of disability and impairment for patients with PD. This article provides a brief introduction to PD and describes the gait changes typically seen in patients with this disease. A major focus of this report is an update on the study of the fractal properties of gait in PD, the relationship between this feature of gait and stride length and gait variability, and the effects of different experimental conditions on these three gait properties. Implications of these findings are also briefly described. This update highlights the idea that while stride length, gait variability, and fractal scaling of gait are all impaired in PD, distinct mechanisms likely contribute to and are responsible for the regulation of these disparate gait properties.
AB - Parkinson's disease (PD) is a common, debilitating neurodegenerative disease. Gait disturbances are a frequent cause of disability and impairment for patients with PD. This article provides a brief introduction to PD and describes the gait changes typically seen in patients with this disease. A major focus of this report is an update on the study of the fractal properties of gait in PD, the relationship between this feature of gait and stride length and gait variability, and the effects of different experimental conditions on these three gait properties. Implications of these findings are also briefly described. This update highlights the idea that while stride length, gait variability, and fractal scaling of gait are all impaired in PD, distinct mechanisms likely contribute to and are responsible for the regulation of these disparate gait properties.
UR - http://www.scopus.com/inward/record.url?scp=67651108895&partnerID=8YFLogxK
U2 - 10.1063/1.3147408
DO - 10.1063/1.3147408
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C2 - 19566273
AN - SCOPUS:67651108895
SN - 1054-1500
VL - 19
JO - Chaos
JF - Chaos
IS - 2
M1 - 026113
ER -