Gadd45 in Preeclampsia

Ossie Geifman-Holtzman, Yali Xiong, Eliezer J. Holtzman

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Preeclampsia is a pregnancy-induced complex of multiple pathological changes. Numerous stresses during pregnancy, including hypoxia, immune activation, inflammatory cytokines, and oxidative stress were reported as contributing factors to the preeclamptic pathology. Seeking common sensors of various stressors in preeclampsia is of new interest and can potentially benefit in disease prevention and treatment. Recent studies have highlighted the role of the Gadd45a protein as a stress sensor in preeclampsia. In response to various pathophysiological stressors, notably hypoxia, oxidative stress, inflammatory cytokines, and AT1-AAs, Gadd45a activates Mkk3-p38 and or JNK signaling. This, in turn, results in immunological and inflammatory changes as well as triggering the production of circulating factors such as sFlt-1, which are believed to account for many of the pathophysiological-related symptoms of preeclampsia. Activation of inflammatory/immune responses in preeclampsia may function in a feedback loop to maintain elevated expression of Gadd45a protein.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages101-108
Number of pages8
DOIs
StatePublished - 2022

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1360
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Circulating factors
  • GADD45
  • Gadd45a
  • Hypoxia
  • Inflammatory cytokines
  • Interleukins
  • MAPK pathway
  • Preeclampsia
  • sFlt-1
  • Stress
  • TNF-alpha

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