TY - CHAP
T1 - Gadd45 in Preeclampsia
AU - Geifman-Holtzman, Ossie
AU - Xiong, Yali
AU - Holtzman, Eliezer J.
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2022
Y1 - 2022
N2 - Preeclampsia is a pregnancy-induced complex of multiple pathological changes. Numerous stresses during pregnancy, including hypoxia, immune activation, inflammatory cytokines, and oxidative stress were reported as contributing factors to the preeclamptic pathology. Seeking common sensors of various stressors in preeclampsia is of new interest and can potentially benefit in disease prevention and treatment. Recent studies have highlighted the role of the Gadd45a protein as a stress sensor in preeclampsia. In response to various pathophysiological stressors, notably hypoxia, oxidative stress, inflammatory cytokines, and AT1-AAs, Gadd45a activates Mkk3-p38 and or JNK signaling. This, in turn, results in immunological and inflammatory changes as well as triggering the production of circulating factors such as sFlt-1, which are believed to account for many of the pathophysiological-related symptoms of preeclampsia. Activation of inflammatory/immune responses in preeclampsia may function in a feedback loop to maintain elevated expression of Gadd45a protein.
AB - Preeclampsia is a pregnancy-induced complex of multiple pathological changes. Numerous stresses during pregnancy, including hypoxia, immune activation, inflammatory cytokines, and oxidative stress were reported as contributing factors to the preeclamptic pathology. Seeking common sensors of various stressors in preeclampsia is of new interest and can potentially benefit in disease prevention and treatment. Recent studies have highlighted the role of the Gadd45a protein as a stress sensor in preeclampsia. In response to various pathophysiological stressors, notably hypoxia, oxidative stress, inflammatory cytokines, and AT1-AAs, Gadd45a activates Mkk3-p38 and or JNK signaling. This, in turn, results in immunological and inflammatory changes as well as triggering the production of circulating factors such as sFlt-1, which are believed to account for many of the pathophysiological-related symptoms of preeclampsia. Activation of inflammatory/immune responses in preeclampsia may function in a feedback loop to maintain elevated expression of Gadd45a protein.
KW - Circulating factors
KW - GADD45
KW - Gadd45a
KW - Hypoxia
KW - Inflammatory cytokines
KW - Interleukins
KW - MAPK pathway
KW - Preeclampsia
KW - Stress
KW - TNF-alpha
KW - sFlt-1
UR - http://www.scopus.com/inward/record.url?scp=85129667395&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-94804-7_7
DO - 10.1007/978-3-030-94804-7_7
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C2 - 35505165
AN - SCOPUS:85129667395
T3 - Advances in Experimental Medicine and Biology
SP - 101
EP - 108
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -