G-CSF enhances the adhesion of encephalitogenic T cells to extracellular matrix components: A possible mechanism for exacerbation of multiple sclerosis

Omri Snir, Gad Lavie, Anat Achiron, Ilan Bank, Taya Ben-Aharon, Benjamin Sredni, Irun R. Cohen, Mathilda Mandel

Research output: Contribution to journalArticlepeer-review

Abstract

Autologous stem cell transplantation is being considered as treatment of severe refractory autoimmune disorders, including MS. Stem cell mobilization is achieved with granulocyte-colony stimulating factor (G-CSF), however, G-CSF administration resulted in cases of worsened clinical MS status. We studied autoreactive T-cell properties, which can promote CNS inflammation in MS. We show that G-CSF enhances MS autoreactive T cell line adhesion to the ECM proteins collagen IV and fibronectin as effectively as the proinflammatory IFNγ and TNFα, known to exacerbate MS symptoms. We propose a link between clinical worsening of MS symptoms induced by G-CSF and the hyperstimulation of T cell adhesion to ECM elicited by G-CSF.

Original languageEnglish
Pages (from-to)145-155
Number of pages11
JournalJournal of Neuroimmunology
Volume172
Issue number1-2
DOIs
StatePublished - Mar 2006

Keywords

  • Autoreactive T cell lines
  • Extracellular matrix
  • G-CSF
  • Multiple sclerosis
  • Pyk2
  • β1-integrins

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