@article{ef7b1521951f4cec83b3bca9fc811bef,
title = "Gα11 and Gαq guaninine nucleotide regulatory proteins differentially modulate the response to thyrotropin-releasing hormone in Xenopus oocytes",
abstract = "Xenopus oocytes that express mouse thyrotropin-releasing hormone receptors (TRH-Rs) after injection if RNA transcribed from TRH-R cDNA respond to THR by a depolarizing current. This response is transducer by activation of phosphoinositide-specific phospholipase C and utilizes an as yet unidentified endogenous guanine nucleotide-binding regulatory (G) protein(s). The α subunit of G11 and Gq have recently been shown to couple receptors to activation of phospholipase C. To determine whether there are functional differences between these proteins, we have co-expressed the TRH-R with either α11 or αq, α11 potentiated the response to TRH (by 61±16%), while αq inhibited the response (by 37±9%). The changes in amplitudes were accompanied by inverse changes in response latencies. These data show that α11 and αq differentially modulate signal transduction in Xenopus oocytes.",
keywords = "G-protein, TRH receptor, Xenopus oocyte",
author = "Dafna Lipinsky and Gershengorn, {Marvin C.} and Yoram Oron",
note = "Funding Information: Acknowledgements: This work was supported by a research ~rant or the US-Israel Binational Science Foundation to Y.O, and M.C.G. It partially fullfils the Ph, D. the~is requirements of D.L,",
year = "1992",
month = jul,
day = "28",
doi = "10.1016/0014-5793(92)80775-C",
language = "אנגלית",
volume = "307",
pages = "237--240",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "2",
}