Future Strategies for Development of Novel BACE Inhibitors: Anti-APP β-Site Antibody and APP Binding Small Molecule Approaches for Alzheimer's Disease

Beka Solomon*, Michal Arbel-Ornath, Clare Peters-Libeu, Varghese John

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations
Original languageEnglish
Title of host publicationBACE
Subtitle of host publicationLead Target for Orchestrated Therapy of Alzheimer's Disease
PublisherJohn Wiley and Sons
Pages217-234
Number of pages18
ISBN (Print)9780470293423
DOIs
StatePublished - 26 Mar 2010

Keywords

  • Alzheimer's disease (AD), progressive neurodegeneration - dementia in elderly
  • Anti β-site antibody mediating inhibition of Aβ production via endocytic pathway
  • Limiting intracellular Aβ formation - at early stages of AD development

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