Future developments in head and neck cancer therapy

INTRODUCTION Recent scientific advances have provided a platform for better understanding the biology of head and neck tumors. We now have a clearer understanding of cancer growth, response to treatment, and patterns of spread. In addition, advanced surgical techniques and the availability of various reconstructive options have improved locoregional control, with parallel improvements in aesthetics and postoperative function. Quality of life is now rightly regarded as a major consideration in the decision process. Despite these advances, the survival of head and neck cancer patients has not significantly improved. The following chapter will provide insight into the major advances achieved so far and into future directions for head and neck cancer therapy and practice.