FUT2 genotype and secretory status are not associated with fecal microbial composition and inferred function in healthy subjects

Williams Turpin, Larbi Bedrani, Osvaldo Espin-Garcia, Wei Xu, Mark S. Silverberg, Michelle I. Smith, David S. Guttman, Anne Griffiths, Paul Moayyedi, Remo Panaccione, Hien Huynh, Hillary Steinhart, Guy Aumais, Konstantin Shestopaloff, Levinus A. Dieleman, Dan Turner, Andrew D. Paterson, Kenneth Croitoru

Research output: Contribution to journalArticlepeer-review

Abstract

Heritability analysis of the microbiota has demonstrated the importance of host genotype in defining the human microbiota. The alpha (1,2)-fucosyltransferase 2 encoded by FUT2 is involved in the formation of the H antigen and the SNP, rs601338 is associated with ABO histo-blood group antigen secretion in the intestinal mucosa. Previous studies have provided non replicated results for the association of this polymorphism with the composition and inferred function of intestinal microbiota. We aimed to assess this relationship in a large cohort of 1,190 healthy individuals. Genotyping was performed using the HumanCoreEXOME chip, microbial composition was addressed by 16S rRNA gene sequencing. Firmicutes, Bacteroidetes, and Actinobacteria were the dominant phyla in this cohort. Although we have sufficient power to detect significant associations of FUT2 genotype/ inferred phenotype with the microbiota, our data demonstrate that FUT2 genotype and secretor status is not associated with microbial alpha diversity, microbial composition or inferred microbial function after correction for multiple testing. Thus, FUT2 genotype and inferred phenotype are not associated with human fecal microbial composition and imputed function.

Original languageEnglish
Pages (from-to)357-368
Number of pages12
JournalGut Microbes
Volume9
Issue number4
DOIs
StatePublished - 4 Jul 2018
Externally publishedYes

Keywords

  • ABO antigen
  • Blood group antigens
  • Fecal microbiota
  • Fucosylation
  • Gut microbiota
  • Healthy human
  • human genetic
  • Microbiome
  • mucus

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