Further Evidence That Malignant Angioendotheliomatosis Is an Angiotropic Large-Cell Lymphoma

Khalil Sheibani*, Hector Battifora, Carl D. Winberg, Jerome S. Burke, Jonathan Ben-Ezra, Gary M. Ellinger, Nelson J. Quigley, Balbino B. Fernandez, Dwight Morrow, Henry Rappaport

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Malignant angioendotheliomatosis is a rare, generally fatal disease characterized by a multifocal proliferation of neoplastic mononuclear cells within the lumens of small blood vessels. Although the disease primarily involves the vasculature of the skin and central nervous system, vascular involvement of other organs may occur and may produce a variety of clinical findings. Some early investigators concluded that malignant angioendotheliomatosis was a neoplasm of endothelial cells, but recently others have suggested that it is of hematopoietic origin. We have studied three patients with the disease and have characterized the immunophenotype of the neoplasm on cryostat-cut fresh-frozen tissues. A detailed antigenic phenotyping of neoplastic lymphoid cells showed that one patient had the immunophenotype T11.

Original languageEnglish
Pages (from-to)943-948
Number of pages6
JournalNew England Journal of Medicine
Volume314
Issue number15
DOIs
StatePublished - 10 Apr 1986
Externally publishedYes

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