Further evidence for the involvement of immunoregulatory processes in corneal alkali burns: Effects of immunosuppression and convalescent serum

Isaac Ben-Hanan, Nahum Landshman, Ehud Assia, Michael Belkin

Research output: Contribution to journalArticlepeer-review

Abstract

Alkali burns were produced in one eye of a group of mice. Two, 3 and 4 weeks later the second eye of each mouse was similarly burned. The rate of perforation in the second-burned eyes was significantly higher than in the first eye. This effect was abolished by immunosuppressing the animals before the burning of the first eyes. This potentiation effect of an ocular burn on subsequent ones is transferable to other mice by intraperitoneal administration of convalescent serum prepared from mice that were previously burned. This evidence suggests that ocular alkali burns cause the appearance in the circulation of antigens not previously present there. The antibodies produced against these antigens exacerbate the subsequent burn lesion and perhaps also the condition of the original burn.

Original languageEnglish
Pages (from-to)288-291
Number of pages4
JournalOphthalmic Research
Volume18
Issue number5
DOIs
StatePublished - 1986

Keywords

  • Convalescent serum
  • Cornea
  • Corneal burns
  • Corneal trauma
  • Immunology
  • Immunosuppression

Fingerprint

Dive into the research topics of 'Further evidence for the involvement of immunoregulatory processes in corneal alkali burns: Effects of immunosuppression and convalescent serum'. Together they form a unique fingerprint.

Cite this