Fungal Priming: Prepare or Perish

Ety Harish, Nir Osherov*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Priming (also referred to as acclimation, acquired stress resistance, adaptive response, or cross-protection) is defined as an exposure of an organism to mild stress that leads to the development of a subsequent stronger and more protective response. This memory of a previously encountered stress likely provides a strong survival advantage in a rapidly shifting environment. Priming has been identified in animals, plants, fungi, and bacteria. Examples include innate immune priming and transgenerational epigenetic inheritance in animals and biotic and abiotic stress priming in plants, fungi, and bacteria. Priming mechanisms are diverse and include alterations in the levels of specific mRNAs, proteins, metabolites, and epigenetic changes such as DNA methylation and histone acetylation of target genes.

Original languageEnglish
Article number448
JournalJournal of Fungi
Issue number5
StatePublished - May 2022


  • acclimation
  • acquired stress resistance
  • adaptive response
  • cross-protection
  • fungal priming


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