@article{292148ae13894aafba3c1414b712da90,
title = "Functional role of AMP-activated protein kinase in the heart during exercise",
abstract = "AMP-activated protein kinase (AMPK) plays a critical role in maintaining energy homeostasis and cardiac function during ischemia in the heart. However, the functional role of AMPK in the heart during exercise is unknown. We examined whether acute exercise increases AMPK activity in mouse hearts and determined the significance of these increases by studying transgenic (TG) mice expressing a cardiac-specific dominant-negative (inactivating) AMPKα2 subunit. Exercise increased cardiac AMPKα2 activity in the wild type mice but not in TG. We found that inactivation of AMPK did not result in abnormal ATP and glycogen consumption during exercise, cardiac function assessed by heart rhythm telemetry and stress echocardiography, or in maximal exercise capacity.",
keywords = "AMP-activated protein kinase, Acetyl CoA carboxylase, Exercise, Heart, p38",
author = "Nicolas Musi and Hirshman, {Michael F.} and Michael Arad and Yanqiu Xing and Nobuharu Fujii and Jason Pomerleau and Ferhaan Ahmad and Berul, {Charles I.} and Seidman, {Jon G.} and Rong Tian and Goodyear, {Laurie J.}",
note = "Funding Information: This work was supported by Grants AR45670 (L.J.G.) and HL67970 (R.T.) from the National Institutes of Health. The work was also supported by an Established Investigator Award from the American Heart Association to Dr. Tian and an American Diabetes Association Mentor Based Award to Dr. Goodyear. We also thank Laura E. Holton for excellent technical assistance. ",
year = "2005",
month = apr,
day = "11",
doi = "10.1016/j.febslet.2005.02.052",
language = "אנגלית",
volume = "579",
pages = "2045--2050",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "10",
}
