Functional role of AMP-activated protein kinase in the heart during exercise

Nicolas Musi, Michael F. Hirshman, Michael Arad, Yanqiu Xing, Nobuharu Fujii, Jason Pomerleau, Ferhaan Ahmad, Charles I. Berul, Jon G. Seidman, Rong Tian, Laurie J. Goodyear*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


AMP-activated protein kinase (AMPK) plays a critical role in maintaining energy homeostasis and cardiac function during ischemia in the heart. However, the functional role of AMPK in the heart during exercise is unknown. We examined whether acute exercise increases AMPK activity in mouse hearts and determined the significance of these increases by studying transgenic (TG) mice expressing a cardiac-specific dominant-negative (inactivating) AMPKα2 subunit. Exercise increased cardiac AMPKα2 activity in the wild type mice but not in TG. We found that inactivation of AMPK did not result in abnormal ATP and glycogen consumption during exercise, cardiac function assessed by heart rhythm telemetry and stress echocardiography, or in maximal exercise capacity.

Original languageEnglish
Pages (from-to)2045-2050
Number of pages6
JournalFEBS Letters
Issue number10
StatePublished - 11 Apr 2005
Externally publishedYes


FundersFunder number
National Institutes of Health
American Diabetes Association
National Heart, Lung, and Blood InstituteR01HL067970
National Institute of Arthritis and Musculoskeletal and Skin DiseasesR01AR045670
American Heart Association


    • AMP-activated protein kinase
    • Acetyl CoA carboxylase
    • Exercise
    • Heart
    • p38


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