@article{e68e5bb5f90b469b8e7d7011a9fe85fd,
title = "Functional role of α7 nicotinic receptor in physiological control of cutaneous homeostasis",
abstract = "Non-neuronal nicotinic acetylcholine receptors (nAChRs) are abundantly expressed in skin and their function remains to be elucidated. Herein, we report that cutaneous α7 nAChR plays a role in the physiological control of cutaneous homeostasis. We studied in vitro effects of functional inactivation of α7 receptor on the expression of apoptosis regulators in keratinocytes (KC) lacking α7 nAChR, and extracellular matrix regulators in the skin of α7 knockout (KO) mice. Elimination of the α7 component of nicotinergic signaling in KC decreased relative amounts of the pro-apoptotic Bad and Bax at both the mRNA and the protein levels, suggesting that α7 nAChR is coupled to stimulation of keratinocyte apoptosis. The skin of α7 KO mice featured decreased amounts of the extracellular matrix proteins collagen 1α1 and elastin as well as the metalloproteinase-1. Taken together, these results suggest an important role for α7 nAChR in mediating plethoric effects of non-neuronal acetylcholine on cutaneous homeostasis.",
keywords = "Knockout mouse, Skin, α7 nicotinic receptor",
author = "Juan Arredondo and Nguyen, {Vu Thuong} and Chernyavsky, {Alexander I.} and Dani Bercovich and Avi Orr-Urtreger and Vetter, {Douglas E.} and Grando, {Sergei A.}",
note = "Funding Information: This work was supported by the NIH grants DE14173 and GM62136, and research grants from the Unilever Research—USA and Flight Attendant Medical Research Institute (to S.A.G.).",
year = "2003",
month = mar,
day = "28",
doi = "10.1016/S0024-3205(03)00084-5",
language = "אנגלית",
volume = "72",
pages = "2063--2067",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "18-19",
}
