TY - JOUR
T1 - Functional MRI research involving healthy children
T2 - Ethics, safety and recommended procedures
AU - Kraus, Dror
AU - Horowitz-Kraus, Tzipi
N1 - Publisher Copyright:
© 2022 Foundation Acta Pædiatrica.
PY - 2022/4
Y1 - 2022/4
N2 - Aim: This specific review aims to expose clinicians, researchers and administrators in hospitals to the importance, procedures and safety of fMRI studies to promote the increased utilisation of such studies in different geographical places worldwide. The child's brain is developing rapidly, both structurally and functionally. These functional changes can only be detected using functional scans generated from an MRI machine and referred to as a functional MRI (fMRI). This method may be used clinically in complex medical and surgical conditions (e.g., epilepsy surgery), but these days are often used for research purposes. However, due to ethical and logistical considerations, fMRI in the paediatric population is not widely and equally used in different geographical places. Conclusions: The benefits of using this method to define the functional changes occurring in the developing brain are discussed in this review, along with desensitisation methods recommended when working with this vulnerable population in research and even in a clinical setting.
AB - Aim: This specific review aims to expose clinicians, researchers and administrators in hospitals to the importance, procedures and safety of fMRI studies to promote the increased utilisation of such studies in different geographical places worldwide. The child's brain is developing rapidly, both structurally and functionally. These functional changes can only be detected using functional scans generated from an MRI machine and referred to as a functional MRI (fMRI). This method may be used clinically in complex medical and surgical conditions (e.g., epilepsy surgery), but these days are often used for research purposes. However, due to ethical and logistical considerations, fMRI in the paediatric population is not widely and equally used in different geographical places. Conclusions: The benefits of using this method to define the functional changes occurring in the developing brain are discussed in this review, along with desensitisation methods recommended when working with this vulnerable population in research and even in a clinical setting.
KW - functional MRI
KW - longitudinal
KW - neuroethics
KW - paediatrics
KW - practical guidelines
UR - http://www.scopus.com/inward/record.url?scp=85124511849&partnerID=8YFLogxK
U2 - 10.1111/apa.16247
DO - 10.1111/apa.16247
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C2 - 34986521
AN - SCOPUS:85124511849
SN - 0803-5253
VL - 111
SP - 741
EP - 749
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
IS - 4
ER -