Functional molecular imaging of tumors by chemical exchange saturation transfer MRI of 3-O-Methyl-DGlucose

Michal Rivlin, Ilan Tsarfaty, Gil Navon

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To evaluate the feasibility to detect tumors and metastases by the chemical exchange saturation transfer (CEST) MRI technique using 3-O-Methyl-D-glucose (3OMG), a nonmetabolizable derivative of glucose that is taken up rapidly and preferentially by tumors and is entirely excreted by the kidneys.

Methods: In vivo CEST MRI experiments were performed on a Bruker 7 Tesla Biospec on implanted orthotopic mammary tumors of mice before and following i.p. injection of 3OMG. The CEST images were generated by a series of gradientecho images collected from a single 1 mm coronal slice after a 1.2 s presaturation pulse, applied at offsets of ±1.2 ppm from the water and at B1 power of 2.5 μT.

Results: Following 3OMG (1.5 g/kg) i.p. injection, an enhanced CEST effect of approximately 20% was visualized at the tumor within a few minutes. The signal slowly declined reaching half of its maximum at approximately 80 min.

Conclusion: Due to the large CEST effect of 3OMG and its low toxicity 3OMG-CEST may serve for the detection of tumors and metastases in the clinic.

Original languageEnglish
Pages (from-to)1375-1380
Number of pages6
JournalMagnetic Resonance in Medicine
Volume72
Issue number5
DOIs
StatePublished - 1 Nov 2014

Keywords

  • 3-O-Methyl-D-glucose
  • Breast cancer
  • Cest
  • Chemical exchange saturation transfer
  • MRI

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