Functional IgG Autoantibodies against Autonomic Nervous System Receptors in Symptomatic Women with Silicone Breast Implants

Efrosiniia Talalai, Denis Gorobets, Gilad Halpert*, Avishai M. Tsur, Harald Heidecke, Yair Levy, Abdulla Watad, Miri Blank, Izhak Michaelevski, Yehuda Shoenfeld, Howard Amital

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The association between the clinical picture of symptomatic women with silicone breast implants (SBI) and dysregulated immunity was in dispute for decades. In the current study, we describe for the first time the functional activity of purified IgG antibodies derived from symptomatic women with SBIs (suffering from subjective/autonomic-related symptoms), both in vitro and in vivo. We found that IgGs, derived from symptomatic women with SBIs, dysregulate inflammatory cytokines (TNFα, IL-6) in activated human peripheral blood mononuclear cells, compared to healthy-women-derived IgGs. Importantly, behavioral studies conducted following intracerebroventricular injection of IgGs derived from symptomatic women with SBIs (who have dysregulated circulating level of IgG autoantibodies directed against autonomic nervous system receptors) into mice brains demonstrated a specific and transient significant increment (about 60%) in the time spent at the center of the open field arena compared with mice injected with IgG from healthy women (without SBIs). This effect was accompanied with a strong trend of reduction of the locomotor activity of the SBI-IgG treated mice, indicating an overall apathic-like behavior. Our study is the first to show the potential pathogenic activity of IgG autoantibodies in symptomatic women with SBIs, emphasizing the importance of these antibodies in SBI-related illness.

Original languageEnglish
Article number1510
JournalCells
Volume12
Issue number11
DOIs
StatePublished - Jun 2023

Funding

FundersFunder number
Yaron and Glia Shemie Foundation

    Keywords

    • G-protein coupled-receptors
    • autoantibodies
    • autonomic nervous system
    • dysautonomia
    • silicone breast implants

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