Functional identification of hot-spot mutations in cardiac calcium channel genes associated with the J wave syndromes

Keyphrases

• Calcium Channel 100%
• Hotspot mutation 100%
• CACNA1C 100%
• J Wave Syndrome 100%
• Functional Identification 100%
• Sudden Cardiac Death 60%
• Family History 40%
• Amino Acid Residues 20%
• Family Members 20%
• Physiological Mechanism 20%
• Proband 20%
• Genome Sequencing 20%
• Exon 2 20%
• Current Density 20%
• Loss Function 20%
• Whole-cell Patch-clamp 20%
• Genetic Screening 20%
• Dominant Negative Effect 20%
• L-type Calcium Channel 20%
• Channel Current 20%
• Calcium Current 20%
• Conserved Amino Acids 20%
• Exon 5 20%
• Brugada Syndrome 20%
• Arrhythmias Cardiac 20%
• Malignant Ventricular Arrhythmia 20%
• Screening Protocol 20%
• Cardiac Channelopathies 20%
• Base Mechanism 20%
• Early Repolarization Syndrome 20%

Biochemistry, Genetics and Molecular Biology

• Calcium Channel 100%
• Sudden Cardiac Death 100%
• Exon 66%
• Amino Acids 33%
• Wild Type 33%
• Genetics 33%
• Proband 33%
• Cardiac Dysrhythmia 33%
• Current Density 33%
• Repolarization 33%
• Whole Cell Patch Clamp 33%
• Channelopathy 33%
• Genetic Screening 33%
• L-Type Calcium Channel 33%
• Calcium Current 33%
• Brugada Syndrome 33%

Medicine and Dentistry

• Calcium Channel 100%
• J Wave 100%
• Exon 40%
• Family History of Sudden Cardiac Death 40%
• Sudden Cardiac Death 20%
• Patch Clamp 20%
• Heart Ventricle Arrhythmia 20%
• Amino Acid 20%
• Genetic Screening 20%
• Whole Cell 20%
• Repolarization 20%
• Calcium Current 20%
• L-Type Calcium Channel 20%
• Brugada Syndrome 20%
• Cardiac Channelopathy 20%