Functional conservation between the human, nematode, and yeast CK2 cell cycle genes

I. Dotan, E. Ziv, N. Dafni, J. S. Beckman, R. O. McCann, C. V.C. Glover, D. Canaani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Protein kinase CK2 (formerly casein kinase II) is a highly conserved serine/threonine protein kinase ubiquitous in eukaryotic organisms. Previously, we have shown that CK2 is required for cell cycle progression and essential for the viability of the yeast Saccharomyces cerevisiae. We now report that either the human or the nematode Caenorhabditis elegans CK2α catalytic subunit can substitute for the yeast catalytic subunits. Additionally, expression of the human CK2 regulatory subunit (CK2β) can suppress the temperature sensitivity of either of the two yeast CK2 mutant catalytic subunits. Taken together, these observations reinforce the view that the CK2 cell cycle progression genes have been highly conserved during evolution from yeast to humans, not only in structure but also in function.

Original languageEnglish
Pages (from-to)603-609
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number3
StatePublished - 2 Nov 2001


FundersFunder number
United States-Israel Binational Science Foundation


    • CKII
    • Yeast cell cycle progression


    Dive into the research topics of 'Functional conservation between the human, nematode, and yeast CK2 cell cycle genes'. Together they form a unique fingerprint.

    Cite this