Functional atlas of the integrin adhesome

Ronen Zaidel-Bar, Shalev Itzkovitz, Avi Ma'ayan, Ravi Iyengar, Benjamin Geiger

Research output: Contribution to journalArticlepeer-review

Abstract

A detailed depiction of the 'integrin adhesome', consisting of a complex network of 156 components linked together and modified by 690 interactions is presented. Different views of the network reveal several functional 'subnets' that are involved in switching on or off many of the molecular interactions within the network, consequently affecting cell adhesion, migration and cytoskeletal organization. Examination of the adhesome network motifs reveals a relatively small number of key motifs, dominated by three-component complexes in which a scaffolding molecule recruits both a signalling molecule and its downstream target. We discuss the role of the different network modules in regulating the structural and signalling functions of cell-matrix adhesions.

Original languageEnglish
Pages (from-to)858-867
Number of pages10
JournalNature Cell Biology
Volume9
Issue number8
DOIs
StatePublished - Aug 2007
Externally publishedYes

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