Functional atlas of the integrin adhesome

Ronen Zaidel-Bar; Shalev Itzkovitz; Avi Ma'ayan; Ravi Iyengar; Benjamin Geiger

doi:10.1038/ncb0807-858

Functional atlas of the integrin adhesome

Ronen Zaidel-Bar^*, Shalev Itzkovitz, Avi Ma'ayan, Ravi Iyengar, Benjamin Geiger

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

947 Scopus citations

Abstract

A detailed depiction of the 'integrin adhesome', consisting of a complex network of 156 components linked together and modified by 690 interactions is presented. Different views of the network reveal several functional 'subnets' that are involved in switching on or off many of the molecular interactions within the network, consequently affecting cell adhesion, migration and cytoskeletal organization. Examination of the adhesome network motifs reveals a relatively small number of key motifs, dominated by three-component complexes in which a scaffolding molecule recruits both a signalling molecule and its downstream target. We discuss the role of the different network modules in regulating the structural and signalling functions of cell-matrix adhesions.

Original language	English
Pages (from-to)	858-867
Number of pages	10
Journal	Nature Cell Biology
Volume	9
Issue number	8
DOIs	https://doi.org/10.1038/ncb0807-858
State	Published - Aug 2007
Externally published	Yes

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abstract = "A detailed depiction of the 'integrin adhesome', consisting of a complex network of 156 components linked together and modified by 690 interactions is presented. Different views of the network reveal several functional 'subnets' that are involved in switching on or off many of the molecular interactions within the network, consequently affecting cell adhesion, migration and cytoskeletal organization. Examination of the adhesome network motifs reveals a relatively small number of key motifs, dominated by three-component complexes in which a scaffolding molecule recruits both a signalling molecule and its downstream target. We discuss the role of the different network modules in regulating the structural and signalling functions of cell-matrix adhesions.",

author = "Ronen Zaidel-Bar and Shalev Itzkovitz and Avi Ma'ayan and Ravi Iyengar and Benjamin Geiger",

note = "Funding Information: This project is funded in part by a National Institutes of Health (NIH) NanoMedicine Center for Mechanical Biology (GM-54508), Advanced Research Center Grant NYSTAR from New York State to R.I. and National Institute of General Medical Science (NIGMS) grant for the Cell Migration Consortium (NIH Grant U54 GM64346), and the United States-Israel Bionational Science Foundation. B.G. holds the Erwin Neter Professorial Chair in Cell and Tumor Biology.",

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AU - Geiger, Benjamin

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Functional atlas of the integrin adhesome

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