Functional alignment of metabolic networks

Arnon Mazza, Allon Wagner, Eytan Ruppin, Roded Sharan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Network alignment has become a standard tool in comparative biology, allowing the inference of protein function, interaction, and orthology. However, current alignment techniques are based on topological properties of networks and do not take into account their functional implications. Here we propose, for the first time, an algorithm to align two metabolic networks by taking advantage of their coupled metabolic models. These models allow us to assess the functional implications of genes or reactions, captured by the metabolic fluxes that are altered following their deletion from the network. Such implications may spread far beyond the region of the network where the gene or reaction lies. We apply our algorithm to align metabolic networks from various organisms, ranging from bacteria to humans, showing that our alignment can reveal functional orthology relations that are missed by conventional topological alignments.

Original languageEnglish
Pages (from-to)390-399
Number of pages10
JournalJournal of Computational Biology
Issue number5
StatePublished - May 2016


  • genome-scale metabolic models
  • metabolic networks
  • network alignment


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