Functional activation of encephalitogenic T cells in the absence of antigen-presenting cells

Boris Reizis*, Felix Mor, Irun R. Cohen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Co-stimulatory signals provided by surface receptors of antigen-presenting cells (APC) are crucial for the activation of CD4+ T cells, classically measured by cell proliferation or IL-2 secretion. The contribution of APC co-stimulatory signals to the acquisition of various effector functions by activated T cells is not fully understood. We have now examined the importance of surfacemediated co-stimulation by APC for activation of the effector potential of T cell clones mediating experimental allergic encephalomyelitis (EAE). We now report that T cell clones can be activated to produce EAE not only with APC but also by antibody-mediated TCR cross-linking in the presence of a mixture of T cell growth factors. Without activation, the T cell clones did not cause EAE. Therefore, at least some types of T cells can be activated to express their effector potential in the absence of any surface co-stimulatory signals requiring intact APC.

Original languageEnglish
Pages (from-to)1375-1379
Number of pages5
JournalInternational Immunology
Volume7
Issue number8
DOIs
StatePublished - Aug 1995
Externally publishedYes

Keywords

  • Antigen-presenting cells
  • Experimental allergic encephalomyelitis
  • T lymphocytes

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