Function and cell distribution of KC-1, a novel natural killer cell associated antigen

C. Clayberger; B. Dyer; B. McIntyre; T. D. Koller; B. Hardy; P. Parham; L. L. Lanier; A. M. Krensky

Function and cell distribution of KC-1, a novel natural killer cell associated antigen

C. Clayberger, B. Dyer, B. McIntyre, T. D. Koller, B. Hardy, P. Parham, L. L. Lanier, A. M. Krensky

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

Natural killer (NK) cells have been implicated in immune responses to tumor and viral antigens. We describe here a monoclonal antibody, anti-KC-1, that blocks lysis of NK targets by fresh but not activated NK cells. Anti-KC-1 has no effect on cytotoxic T lymphocyte activity or on antibody-dependent cellular cytotoxicity. This antibody may be useful in the analysis of NK cell activation and the mechanism of lysis.

Original language	English
Pages (from-to)	1537-1541
Number of pages	5
Journal	Journal of Immunology
Volume	136
Issue number	5
State	Published - 1986

Cite this

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abstract = "Natural killer (NK) cells have been implicated in immune responses to tumor and viral antigens. We describe here a monoclonal antibody, anti-KC-1, that blocks lysis of NK targets by fresh but not activated NK cells. Anti-KC-1 has no effect on cytotoxic T lymphocyte activity or on antibody-dependent cellular cytotoxicity. This antibody may be useful in the analysis of NK cell activation and the mechanism of lysis.",

author = "C. Clayberger and B. Dyer and B. McIntyre and Koller, {T. D.} and B. Hardy and P. Parham and Lanier, {L. L.} and Krensky, {A. M.}",

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AU - Clayberger, C.

AU - Dyer, B.

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AU - Hardy, B.

AU - Parham, P.

AU - Lanier, L. L.

AU - Krensky, A. M.

PY - 1986

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AB - Natural killer (NK) cells have been implicated in immune responses to tumor and viral antigens. We describe here a monoclonal antibody, anti-KC-1, that blocks lysis of NK targets by fresh but not activated NK cells. Anti-KC-1 has no effect on cytotoxic T lymphocyte activity or on antibody-dependent cellular cytotoxicity. This antibody may be useful in the analysis of NK cell activation and the mechanism of lysis.

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Function and cell distribution of KC-1, a novel natural killer cell associated antigen

Abstract

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