TY - JOUR
T1 - Fulminant ectopic Cushing syndrome in a patient with metastatic neuroendocrine carcinoma and Crohn's disease
AU - Gorshtein, Alexander
AU - Strenov, Yulia
AU - Mor, Eytan
AU - Shimon, Ilan
AU - Grozinsky-Glasberg, Simona
PY - 2011
Y1 - 2011
N2 - Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) have been rarely reported in patients with Crohn's disease, being usually small and incidentally detected in areas uninvolved by the inflammatory process. We describe the case of a young female patient with Crohn's disease and a fulminant Cushing's syndrome induced by the ectopic secretion of adrenocorticotropic hormone (ACTH) by an aggressive gastrointestinal neuroendocrine carcinoma (NEC). Despite a multi-therapeutic approach, including the administration of multiple courses of chemotherapy, hypo-cortisolemic agents, somatostatin analogues, as well as the performance of bilateral adrenal vein embolization followed by bilateral adrenalectomy, patient's condition progressively deteriorated and she died nine months after the diagnosis of NEC due to liver failure. The available literature addressing the possible connection between Crohn's disease and NEC is discussed in detail.
AB - Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) have been rarely reported in patients with Crohn's disease, being usually small and incidentally detected in areas uninvolved by the inflammatory process. We describe the case of a young female patient with Crohn's disease and a fulminant Cushing's syndrome induced by the ectopic secretion of adrenocorticotropic hormone (ACTH) by an aggressive gastrointestinal neuroendocrine carcinoma (NEC). Despite a multi-therapeutic approach, including the administration of multiple courses of chemotherapy, hypo-cortisolemic agents, somatostatin analogues, as well as the performance of bilateral adrenal vein embolization followed by bilateral adrenalectomy, patient's condition progressively deteriorated and she died nine months after the diagnosis of NEC due to liver failure. The available literature addressing the possible connection between Crohn's disease and NEC is discussed in detail.
KW - Carcinoid
KW - Cortisol
KW - Crohn's disease
KW - Ectopic Cushing's syndrome
KW - Immunosuppression
KW - Neuroendocrine tumor
UR - http://www.scopus.com/inward/record.url?scp=84857389023&partnerID=8YFLogxK
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C2 - 22286792
AN - SCOPUS:84857389023
SN - 0172-780X
VL - 32
SP - 735
EP - 740
JO - Neuroendocrinology Letters
JF - Neuroendocrinology Letters
IS - 6
ER -