Fulminant Cutaneous T‐cell Lymphoma and Sézary Syndrome

ABSTRACT: The term cutaneous T‐tell lymphoma (CTCL) has recently been coined to describe a group of rare lymphoproliferative T‐cell disorders classically beginning in the skin and pursuing a chronic, progressive, and indolent course eventually followed by visceral involvement. This term encompasses the spectrum of the traditional mycosis fungoides and Sézary syndrome. A unique case of CTCL that developed a fulminant course leading to death within a few months following the initial symptoms is presented. The clinical course bears a striking similarity to a group of acute T‐cell malignancies, while the cytologic‐pathologic findings favor the diagnosis of Sźary syndrome. Regardless ot the exact classifications, this entity appears to be a highly malignant T‐cell disorder, resistant to chemotherapy.