FTO: Linking m6a demethylation to adipogenesis

Moshe Shay Ben-Haim, Sharon Moshitch-Moshkovitz, Gideon Rechavi*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

Abstract

Polymorphism of the FTO gene encoding an N6-methyladenosine (m6A) RNA demethylase was robustly associated with human obesity; however, the mechanism by which FTO affects metabolism, considering its emerging role in RNA modification, is still poorly understood. A new study published in Cell Research reports novel functions implicating FTO in the regulation of mRNA alternative splicing in the control of adipogenesis.

Original languageEnglish
Pages (from-to)3-4
Number of pages2
JournalCell Research
Volume25
Issue number1
DOIs
StatePublished - 5 Jan 2015

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