From thrombasthenia to next generation thrombocytopenia: Neonatal alloimmune thrombocytopenia induced by maternal Glanzmann thrombasthenia

Assaf Arie Barg, Hagit Hauschner, Jacob Luboshitz, Tami Livnat, Tzipi Straus, Sarina Levy-Mendelovich, Aharon Lubetsky, Nurit Rosenberg, Gili Kenet

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Glanzmann thrombasthenia (GT) is a rare autosomal recessive disorder of platelet function caused by mutations in the genes coding for integrin αIIbβ3. The aim of this study was to examine the outcome of newborns of GT mothers, with emphasis on thrombocytopenia and bleeding manifestations and their relation to maternal antiplatelet antibodies. Procedure: Medical files of all female patients with GT treated in a single tertiary center from 1999 to 2017 were searched for details on pregnancy and birth. The medical files of their newborns were retrieved, and data on the postnatal course were collected. Results: Nine babies were born to five patients with GT at our center during the study period. Three of the nine newborns had severe thrombocytopenia, and all three were offspring of GT mothers who were positive for antiplatelet antibodies. Conclusion: Pregnant GT patients should be examined for platelet antibodies. Assessment and management protocols (including treatment with intravenous immunoglobulins) for fetal and neonatal alloimmune thrombocytopenia should be considered.

Original languageEnglish
Article numbere27376
JournalPediatric Blood and Cancer
Volume65
Issue number12
DOIs
StatePublished - Dec 2018
Externally publishedYes

Keywords

  • Glanzmann thrombasthenia
  • neonatal alloimmune thrombocytopenia
  • pregnancy

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