From sentinel cells to inflammatory culprits: Cancer-associated fibroblasts in tumour-related inflammation

Charlotte Servais, Neta Erez*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Inflammation is now established as a hallmark of cancer. Cancer-associated fibroblasts (CAFs) have been established as a key component of the crosstalk between tumour cells and their microenvironment. Central to the role of CAFs in facilitating tumour growth, invasion, and metastasis is their ability to orchestrate tumour-related inflammation. CAFs and their soluble mediators provide multiple complex regulatory signals that modulate the trafficking, differentiation status, and function of inflammatory cells in the tumour microenvironment. This review focuses on pathways by which CAFs mediate tumour-promoting inflammation and modify the components of the inflammatory microenvironment that facilitate tumour initiation, progression, and metastasis.

Original languageEnglish
Pages (from-to)198-207
Number of pages10
JournalJournal of Pathology
Volume229
Issue number2
DOIs
StatePublished - Jan 2013

Keywords

  • cancer
  • cancer-associated fibroblasts
  • inflammation
  • metastasis

Fingerprint

Dive into the research topics of 'From sentinel cells to inflammatory culprits: Cancer-associated fibroblasts in tumour-related inflammation'. Together they form a unique fingerprint.

Cite this