From rheumatic fever to Libman-Sacks endocarditis: Is there any possible pathogenetic link?

M. Blank, A. Aron-Maor, Yehuda Shoenfeld

Research output: Contribution to journalReview articlepeer-review

Abstract

The heart lesions of rheumatic fever and the heart involvement in antiphospholipid syndrome (APS), have different clinical pictures. Yet, there are several common characteristics linking both diseases: 1) central nervous system (CNS) and heart involvement; 2) molecular mimicry between the a pathogen and the origin of the disease; 3) cross reacting antibodies between the pathogen and self molecules; 4) endothelial cell activation in the 'crime-area' i.e., the valves; 5) some of the patients with RF have circulating antiphospholipid antibodies, while APS may be associated with streptococcal infection; and 6) recently, a cross-reactivity between antibodies directed to the streptococcal M-protein and its synthetic derivative in rheumatic fever (RF) and antibodies derived from APS patients targeting the beta-2-glycoprotein-I (β2GPI) and a β2GPI related synthetic peptide. In the current paper, we summarize the possible links between the heart involvement in RF and APS.

Original languageEnglish
Pages (from-to)697-701
Number of pages5
JournalLupus
Volume14
Issue number9
DOIs
StatePublished - 2005

Keywords

  • Anti-β2GPI
  • Antiphosphplipid syndrome
  • Autoimmunity
  • Libman-Sacks endocarditis
  • M-protein
  • Rheumatic fever

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