TY - JOUR
T1 - From patient centered risk factors to comprehensive prognostic models
T2 - A suggested framework for outcome prediction in umbilical cord blood transplantation
AU - Shouval, Roni
AU - Nagler, Arnon
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Prospectively identifying patients who will gain maximal benefit from umbilical cord blood transplantation (UCBT) with minimal risk is a desirable unmet need. A complex network of parameters related to patient, disease, donor, and procedure all come into play. We review the prognostic role of patientrelated risk factors in adults undergoing UCBT. Furthermore, since comprehensive prognostic models are lacking in UCBT, we suggest a framework for integrating patients' features in the development of prediction models for UCBT outcomes. Such models could contribute to patient selection, optimization of the various modifiable features in the process of UCBT, analysis of retrospective data, and design of interventions.
AB - Prospectively identifying patients who will gain maximal benefit from umbilical cord blood transplantation (UCBT) with minimal risk is a desirable unmet need. A complex network of parameters related to patient, disease, donor, and procedure all come into play. We review the prognostic role of patientrelated risk factors in adults undergoing UCBT. Furthermore, since comprehensive prognostic models are lacking in UCBT, we suggest a framework for integrating patients' features in the development of prediction models for UCBT outcomes. Such models could contribute to patient selection, optimization of the various modifiable features in the process of UCBT, analysis of retrospective data, and design of interventions.
KW - Predictive modeling
KW - Risk factors
KW - Umbilical cord blood transplantation (UCBT)
UR - http://www.scopus.com/inward/record.url?scp=85019541702&partnerID=8YFLogxK
U2 - 10.21037/sci.2017.05.06
DO - 10.21037/sci.2017.05.06
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
AN - SCOPUS:85019541702
SN - 2306-9759
VL - 2017
JO - Stem Cell Investigation
JF - Stem Cell Investigation
IS - MAY
M1 - 39
ER -