@article{e5dfbabc33bb4a648a1f07dd8fa85dd8,
title = "From circadian sleep disruption to Neuroprotection: The potential of VIP/PACAP in Alzheimer's disease treatment",
abstract = "Alzheimer's Disease (AD) represents a significant neurodegenerative challenge with current therapeutic strategies primarily focused on symptomatic management. This review explores the relationship between disrupted circadian rhythms, AD and the critical involvement of vasoactive intestinal peptide (VIP) and adenylate cyclase-activating polypeptide (PACAP) signaling pathways. These pathways hold promise for new drug development and provide insights into the complex pathogenesis of AD. Enhancement of brain bioavailability through advanced drug delivery systems is proposed and reviewed.",
keywords = "ADNP, Alzheimer's Disease, Circadian Clock, PACAP, Tauopathy, VIP",
author = "Artur Galushkin and Illana Gozes",
note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",
year = "2024",
month = jan,
doi = "10.1016/j.crbiot.2024.100254",
language = "אנגלית",
volume = "8",
journal = "Current Research in Biotechnology",
issn = "2590-2628",
publisher = "Elsevier B.V.",
}