Frog brain and liver show evolutionary conservation of tissue-specific differences among insulin receptors

Celeste Hart, Joshua Shemer, Juan C. Penhos, Maxine A. Lesniak, Jesse Roth, Derek LeRoith

Research output: Contribution to journalArticlepeer-review

Abstract

The insulin receptors of frog brain and liver show features typical of other insulin receptors with regard to affinity and specificity of binding to insulins and proinsulin, solubility in Triton X-100, binding to and elution from wheat germ agglutinin, and insulin-sensitive tyrosine kinase activity. Likewise, the brain and liver receptors differ from one another in electrophoretic mobility and susceptibility to treatment with neuraminidase, analogous to brain and liver receptors of reptiles, birds, and mammals; while the functional implications of these differences are unknown, their evolutionary conservation for 400-500 million years suggests the possibility that they might have importance.

Original languageEnglish
Pages (from-to)170-178
Number of pages9
JournalGeneral and Comparative Endocrinology
Volume68
Issue number2
DOIs
StatePublished - Nov 1987
Externally publishedYes

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