Fresh Molecular Concepts to Extend the Lifetimes of Old Antimicrobial Drugs

Qais Z. Jaber, Micha Fridman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Antimicrobial drug development generally initiates with target identification and mode of action studies. Often, emergence of resistance and/or undesired side effects that are discovered only after prolonged clinical use, result in discontinuation of clinical use. Since the cost and time required for improvement of existing drugs are considerably lower than those required for the development of novel drugs, academic and pharmaceutical company researchers pursue this direction. In this account we describe selected examples of how chemical probes generated from antimicrobial drugs and chemical and enzymatic modifications of these drugs have been used to modify modes of action, block mechanisms of resistance, or reduce side effects, improving performance. These examples demonstrate how new and comprehensive mechanistic insights can be translated into fresh concepts for development of next-generation antimicrobial agents.

Original languageEnglish
Pages (from-to)631-645
Number of pages15
JournalChemical Record
Volume21
Issue number4
DOIs
StatePublished - Apr 2021

Funding

FundersFunder number
Israel Science Foundation179/19

    Keywords

    • Antifungal agents
    • Antimicrobial Cationic Amphiphiles
    • Antimicrobial Drug Hybrides
    • Antimicrobial agents
    • Fluorescent Probes of Antimicrobial Drugs

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