Frequent ploidy changes in growing yeast cultures

Yaniv Harari, Yoav Ram, Martin Kupiec*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Ploidy is considered a very stable cellular characteristic. Although rare, changes in ploidy play important roles in the acquisition of long-term adaptations. Since these duplications allow the subsequent loss of individual chromosomes and accumulation of mutations, changes in ploidy can also cause genomic instability, and have been found to promote cancer. Despite the importance of the subject, measuring the rate of whole-genome duplications has proven extremely challenging. We have recently measured the rate of diploidization in yeast using long-term, in-lab experiments. We found that spontaneous diploidization occurs frequently, by two different mechanisms: endoreduplication and mating type switching. Despite its common occurrence, spontaneous diploidization is usually selected against, although it can be advantageous under some stressful conditions. Our results have implications for the understanding of evolutionary processes, as well as for the use of yeast cells in biotechnological applications.

Original languageEnglish
Pages (from-to)1001-1004
Number of pages4
JournalCurrent Genetics
Issue number5
StatePublished - 1 Oct 2018


FundersFunder number
Minerva Foundation
Volkswagen Foundation
Israel Science Foundation


    • Diploid
    • Endoreduplication
    • Genome duplication
    • Haploid
    • Heterothalism
    • Homologous recombination
    • Homothallism
    • Ploidy
    • Saccharomyces cerevisiae


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