TY - JOUR
T1 - Frequency of gastroesophageal reflux events induced by pharyngeal water stimulation in young and elderly subjects
AU - Xie, Pengyan
AU - Ren, Junlong
AU - Bardan, Eytan
AU - Mittal, Ravinder K.
AU - Sui, Zhumei
AU - Shaker, Reza
PY - 1997/2
Y1 - 1997/2
N2 - Earlier studies hove shown that isolated complete lower esophageal sphincter (LES) relaxation occurs as a result of pharyngeal water stimulation. Association of these relaxations with gastroesophageal reflux has not been studied systematically. Our aim was to determine this association in young and elderly subjects during precibal and postprandial periods. We studied 8 young subjects and 10 elderly subjects for i h before and 2 h after a 1,000-cal meal. In both groups, during the precibal period, negligible LES relaxation induced by pharyngeal water stimulation resulted in gastroesophageal reflux. In the postprandial period, gastroesophageal reflux events occurred after 16% of pharyngeal water injections in young subjects and after 44% in elderly subjects (P < 0.05). Intra-abdominal length of the LES in elderly subjects was significantly shorter compared with younger subjects (P < 0.05). We conclude that gastroesophageal reflux events induced by pharyngeal water stimulation in the postprandial period are significantly increased compared with those of the precibal period and are significantly more prevalent in the elderly compared with the young. These differences seem to be associated with a significantly shorter intra-abdominal segment of the LES in the elderly.
AB - Earlier studies hove shown that isolated complete lower esophageal sphincter (LES) relaxation occurs as a result of pharyngeal water stimulation. Association of these relaxations with gastroesophageal reflux has not been studied systematically. Our aim was to determine this association in young and elderly subjects during precibal and postprandial periods. We studied 8 young subjects and 10 elderly subjects for i h before and 2 h after a 1,000-cal meal. In both groups, during the precibal period, negligible LES relaxation induced by pharyngeal water stimulation resulted in gastroesophageal reflux. In the postprandial period, gastroesophageal reflux events occurred after 16% of pharyngeal water injections in young subjects and after 44% in elderly subjects (P < 0.05). Intra-abdominal length of the LES in elderly subjects was significantly shorter compared with younger subjects (P < 0.05). We conclude that gastroesophageal reflux events induced by pharyngeal water stimulation in the postprandial period are significantly increased compared with those of the precibal period and are significantly more prevalent in the elderly compared with the young. These differences seem to be associated with a significantly shorter intra-abdominal segment of the LES in the elderly.
KW - aging
KW - aging and lower esophageal sphincter length
KW - intra-abdominal and intrathoracic lower esophageal sphincter length
KW - lower esophageal sphincter length
KW - lower esophageal sphincter relaxation
KW - pharyngeal sensory impulses
UR - https://www.scopus.com/pages/publications/0030938682
U2 - 10.1152/ajpgi.1997.272.2.g233
DO - 10.1152/ajpgi.1997.272.2.g233
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C2 - 9124346
AN - SCOPUS:0030938682
SN - 0193-1857
VL - 272
SP - G233-G237
JO - American Journal of Physiology - Gastrointestinal and Liver Physiology
JF - American Journal of Physiology - Gastrointestinal and Liver Physiology
IS - 2 35-2
ER -