Frequency of gastroesophageal reflux events induced by pharyngeal water stimulation in young and elderly subjects

Pengyan Xie, Junlong Ren, Eytan Bardan, Ravinder K. Mittal, Zhumei Sui, Reza Shaker

Research output: Contribution to journalArticlepeer-review

Abstract

Earlier studies hove shown that isolated complete lower esophageal sphincter (LES) relaxation occurs as a result of pharyngeal water stimulation. Association of these relaxations with gastroesophageal reflux has not been studied systematically. Our aim was to determine this association in young and elderly subjects during precibal and postprandial periods. We studied 8 young subjects and 10 elderly subjects for i h before and 2 h after a 1,000-cal meal. In both groups, during the precibal period, negligible LES relaxation induced by pharyngeal water stimulation resulted in gastroesophageal reflux. In the postprandial period, gastroesophageal reflux events occurred after 16% of pharyngeal water injections in young subjects and after 44% in elderly subjects (P < 0.05). Intra-abdominal length of the LES in elderly subjects was significantly shorter compared with younger subjects (P < 0.05). We conclude that gastroesophageal reflux events induced by pharyngeal water stimulation in the postprandial period are significantly increased compared with those of the precibal period and are significantly more prevalent in the elderly compared with the young. These differences seem to be associated with a significantly shorter intra-abdominal segment of the LES in the elderly.

Original languageEnglish
Pages (from-to)G233-G237
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume272
Issue number2 35-2
DOIs
StatePublished - Feb 1997
Externally publishedYes

Keywords

  • aging
  • aging and lower esophageal sphincter length
  • intra-abdominal and intrathoracic lower esophageal sphincter length
  • lower esophageal sphincter length
  • lower esophageal sphincter relaxation
  • pharyngeal sensory impulses

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