TY - JOUR
T1 - Frailty and Falls in People Living With Multiple Sclerosis
AU - Zanotto, Tobia
AU - Galperin, Irina
AU - Mirelman, Anat
AU - Yehezkiyahu, Shahar
AU - Estes, John
AU - Chen, Lingjun
AU - Regev, Keren
AU - Karni, Arnon
AU - Schmitz-Hübsch, Tanja
AU - Paul, Friedemann
AU - Lynch, Sharon G.
AU - Akinwuntan, Abiodun E.
AU - Devos, Hannes
AU - Hausdorff, Jeffrey M.
AU - Sosnoff, Jacob J.
N1 - Publisher Copyright:
© 2022
PY - 2022/5
Y1 - 2022/5
N2 - Objective: To explore the association between frailty and history of falls in people living with multiple sclerosis (MS). Design: Secondary analysis. Setting: University research laboratories in the United States and Israel. Participants: A total of 118 people (N=118) with relapsing-remitting MS (mean age, 48.9±10.0 years; 74.6% female; Expanded Disability Status Scale [EDSS] range, 1.0-6.0) were studied in this cross-sectional analysis. Intervention: Not applicable. Main Outcome Measures: A frailty index was calculated from 40 health deficits by following standard validated procedures. The number of falls (12-month history) was recorded. Results: Overall, 33.9%, 29.7%, and 36.4% of participants were classified as nonfrail, moderately frail, and severely frail, respectively. The frailty index was significantly correlated (ρ=0.37, P<.001) with higher scores on the EDSS. In univariable negative binomial regression analysis, the frailty index was associated with a higher number of falls (incidence rate ratio [IRR]=3.33; 95% CI, 1.85-5.99; P<.001). After adjustment for age, sex, and EDSS, frailty remained strongly associated with history of falls (IRR=2.78; 95% CI, 1.51-5.10; P=.001). Conclusions: The current study identifies a significant relationship between frailty and history of falls in MS, independent of age, sex, and disease severity. These findings support the notion that frailty is a syndrome related to but independent of disability in MS.
AB - Objective: To explore the association between frailty and history of falls in people living with multiple sclerosis (MS). Design: Secondary analysis. Setting: University research laboratories in the United States and Israel. Participants: A total of 118 people (N=118) with relapsing-remitting MS (mean age, 48.9±10.0 years; 74.6% female; Expanded Disability Status Scale [EDSS] range, 1.0-6.0) were studied in this cross-sectional analysis. Intervention: Not applicable. Main Outcome Measures: A frailty index was calculated from 40 health deficits by following standard validated procedures. The number of falls (12-month history) was recorded. Results: Overall, 33.9%, 29.7%, and 36.4% of participants were classified as nonfrail, moderately frail, and severely frail, respectively. The frailty index was significantly correlated (ρ=0.37, P<.001) with higher scores on the EDSS. In univariable negative binomial regression analysis, the frailty index was associated with a higher number of falls (incidence rate ratio [IRR]=3.33; 95% CI, 1.85-5.99; P<.001). After adjustment for age, sex, and EDSS, frailty remained strongly associated with history of falls (IRR=2.78; 95% CI, 1.51-5.10; P=.001). Conclusions: The current study identifies a significant relationship between frailty and history of falls in MS, independent of age, sex, and disease severity. These findings support the notion that frailty is a syndrome related to but independent of disability in MS.
KW - Accidental falls
KW - Aging
KW - Frailty
KW - Multiple sclerosis
KW - Rehabilitation
UR - https://www.scopus.com/pages/publications/85122992699
U2 - 10.1016/j.apmr.2021.10.025
DO - 10.1016/j.apmr.2021.10.025
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C2 - 34838587
AN - SCOPUS:85122992699
SN - 0003-9993
VL - 103
SP - 952
EP - 957
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
IS - 5
ER -