TY - JOUR
T1 - Fragile X expression in Martin-Bell syndrome, intellectually normal individuals, and neoplasia, interpreted by a viral hypothesis
AU - Shabtai, F.
AU - Hart, J.
AU - Klar, D.
AU - Bichacho, S.
AU - Halbrecht, I.
PY - 1988
Y1 - 1988
N2 - We present data on fragile X expression in lymphocytes obtained from the following patients: a university student, an infertile couple, 6 of 22 prostatic cancer patients, a meningioma patient, and members of families with meningioma and familial gliomas. All patients were of normal intelligence. In addition, we report 3 cases of central nervous system (CNS) tumors in more typical fragile X families. We suggest that the fragile X expression as well as the clinical findings may be caused by a viral (or similar) infection. The virus may require a receptor protein coded by one allele of a gene on the X chromosome.
AB - We present data on fragile X expression in lymphocytes obtained from the following patients: a university student, an infertile couple, 6 of 22 prostatic cancer patients, a meningioma patient, and members of families with meningioma and familial gliomas. All patients were of normal intelligence. In addition, we report 3 cases of central nervous system (CNS) tumors in more typical fragile X families. We suggest that the fragile X expression as well as the clinical findings may be caused by a viral (or similar) infection. The virus may require a receptor protein coded by one allele of a gene on the X chromosome.
UR - http://www.scopus.com/inward/record.url?scp=0023789415&partnerID=8YFLogxK
U2 - 10.1002/ajmg.1320300172
DO - 10.1002/ajmg.1320300172
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 3177480
AN - SCOPUS:0023789415
SN - 0148-7299
VL - 30
SP - 697
EP - 702
JO - American Journal of Medical Genetics
JF - American Journal of Medical Genetics
IS - 1-2
ER -
