A cell lined with Teflon fluorocarbon resin, containing a silver halide (AgBr/AgCI) Infrared fiber, allows convenient and reproducible loading of organic solutions and solids (amorphous or crystalline) derived by evaporation of the solvent. Attenuated total Internal reflectance (ATR) measurements with a Fourier transform Infrared (FT-IR) spectrometer are reported for organic compounds. Known spectroscopic features can be recognized with quantities as small as 6 ng (ca. 1/20th of a monolayer). Usable spectra are obtainable with 100-ng quantities (1 monolayer), and high-quality spectra are measurable with 10-/μg quantities. Absorbance is linear up to ca. 600 monolayers (0.55-μm layer thickness), the limit of absorption being ca. O.9-μm layer thickness (about 1000 molecular layers).