TY - JOUR
T1 - Four-year results of a prospective-controlled clinical study evaluating healing of intra-bony defects following treatment with an enamel matrix protein derivative alone or combined with a bioactive glass
AU - Sculean, Anton
AU - Pietruska, Malgorzata
AU - Arweiler, Nicole B.
AU - Auschill, Thorsten M.
AU - Nemcovsky, Carlos
PY - 2007/6
Y1 - 2007/6
N2 - Aim: To evaluate the 4-year results following regenerative periodontal surgery at intra-bony defects with either a combination of an enamel matrix protein derivative (EMD) and a bioactive glass (BG) or with EMD alone. Methods: Twenty-five patients with one deep intra-bony defect each were randomly treated with either an EMD+BG (test) or with EMD alone (control). Measurements were recorded at baseline, at 1 and at 4 years following therapy. The primary outcome variable was the clinical attachment level (CAL). Results: The test group demonstrated a mean CAL change from 10.3±1.6 to 6.7±1.2 mm (p<0.001) and to 6.9±1.0 mm (p<0.001) at 1 and 4 years, respectively. No statistically significant differences were found between the 1- and 4-year results. The control group showed a mean CAL change from 10.4±1.6 to 6.7±1.1 mm (p<0.001) at 1 year and 7.0±0.9 mm (p<0.001) at 4 years. The CAL change between 1 and 4 years did not present statistically significant differences. In each of the two groups, four defects have lost 1 mm of the CAL gained at 1 year. A CAL gain of 1 mm compared with the 1-year results was measured in only one defect of the test group. Compared with baseline, a CAL gain of ≥3 mm was found at 4 years in 10 defects in both groups. Between the treatment groups, no statistically significant differences in any of the investigated parameters were observed at 1 and at 4 years. Conclusion: Within their limits, the present results indicate that the clinical improvements obtained with both regenerative modalities can be maintained over a period of 4 years.
AB - Aim: To evaluate the 4-year results following regenerative periodontal surgery at intra-bony defects with either a combination of an enamel matrix protein derivative (EMD) and a bioactive glass (BG) or with EMD alone. Methods: Twenty-five patients with one deep intra-bony defect each were randomly treated with either an EMD+BG (test) or with EMD alone (control). Measurements were recorded at baseline, at 1 and at 4 years following therapy. The primary outcome variable was the clinical attachment level (CAL). Results: The test group demonstrated a mean CAL change from 10.3±1.6 to 6.7±1.2 mm (p<0.001) and to 6.9±1.0 mm (p<0.001) at 1 and 4 years, respectively. No statistically significant differences were found between the 1- and 4-year results. The control group showed a mean CAL change from 10.4±1.6 to 6.7±1.1 mm (p<0.001) at 1 year and 7.0±0.9 mm (p<0.001) at 4 years. The CAL change between 1 and 4 years did not present statistically significant differences. In each of the two groups, four defects have lost 1 mm of the CAL gained at 1 year. A CAL gain of 1 mm compared with the 1-year results was measured in only one defect of the test group. Compared with baseline, a CAL gain of ≥3 mm was found at 4 years in 10 defects in both groups. Between the treatment groups, no statistically significant differences in any of the investigated parameters were observed at 1 and at 4 years. Conclusion: Within their limits, the present results indicate that the clinical improvements obtained with both regenerative modalities can be maintained over a period of 4 years.
KW - Bioactive glass
KW - Controlled clinical study
KW - Enamel matrix protein derivative
KW - Long-term results
KW - Regenerative periodontal therapy
UR - http://www.scopus.com/inward/record.url?scp=34248549142&partnerID=8YFLogxK
U2 - 10.1111/j.1600-051X.2007.01084.x
DO - 10.1111/j.1600-051X.2007.01084.x
M3 - מאמר
C2 - 17451415
AN - SCOPUS:34248549142
VL - 34
SP - 507
EP - 513
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
SN - 0303-6979
IS - 6
ER -