Four-year results of a prospective-controlled clinical study evaluating healing of intra-bony defects following treatment with an enamel matrix protein derivative alone or combined with a bioactive glass

Anton Sculean*, Malgorzata Pietruska, Nicole B. Arweiler, Thorsten M. Auschill, Carlos Nemcovsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To evaluate the 4-year results following regenerative periodontal surgery at intra-bony defects with either a combination of an enamel matrix protein derivative (EMD) and a bioactive glass (BG) or with EMD alone. Methods: Twenty-five patients with one deep intra-bony defect each were randomly treated with either an EMD+BG (test) or with EMD alone (control). Measurements were recorded at baseline, at 1 and at 4 years following therapy. The primary outcome variable was the clinical attachment level (CAL). Results: The test group demonstrated a mean CAL change from 10.3±1.6 to 6.7±1.2 mm (p<0.001) and to 6.9±1.0 mm (p<0.001) at 1 and 4 years, respectively. No statistically significant differences were found between the 1- and 4-year results. The control group showed a mean CAL change from 10.4±1.6 to 6.7±1.1 mm (p<0.001) at 1 year and 7.0±0.9 mm (p<0.001) at 4 years. The CAL change between 1 and 4 years did not present statistically significant differences. In each of the two groups, four defects have lost 1 mm of the CAL gained at 1 year. A CAL gain of 1 mm compared with the 1-year results was measured in only one defect of the test group. Compared with baseline, a CAL gain of ≥3 mm was found at 4 years in 10 defects in both groups. Between the treatment groups, no statistically significant differences in any of the investigated parameters were observed at 1 and at 4 years. Conclusion: Within their limits, the present results indicate that the clinical improvements obtained with both regenerative modalities can be maintained over a period of 4 years.

Original languageEnglish
Pages (from-to)507-513
Number of pages7
JournalJournal of Clinical Periodontology
Volume34
Issue number6
DOIs
StatePublished - Jun 2007

Keywords

  • Bioactive glass
  • Controlled clinical study
  • Enamel matrix protein derivative
  • Long-term results
  • Regenerative periodontal therapy

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