Four new C16 1,2-dioxene-polyketides from the sponge plakortis aff. Simplex

Amira Rudi; Ravit Talpir; Yoel Kashman; Yehuda Benayahu; Michael Schleyer

doi:10.1021/np50102a023

Four new C₁₆ 1,2-dioxene-polyketides from the sponge plakortis aff. Simplex

Amira Rudi, Ravit Talpir, Yoel Kashman^*, Yehuda Benayahu, Michael Schleyer

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Two new cyclic peroxide-containing polyketide C₁₆ acids 2 and 4 with their methyl esters 3 and 5 have been isolated from the Indo-Pacific marine sponge Plakortis aff. simplex. Both 2 and 3 are proposed to contain a single 1,2-dioxene ring, while 4 and 5 incorporate two 1,2-dioxene rings. The structures were elucidated mainly through 1D and 2D nmr spectral analysis. The methyl esters 3 and 5 were found to be active against cultured P-388 murine leukemia cells.

Original language	English
Pages (from-to)	2178-2182
Number of pages	5
Journal	Journal of Natural Products
Volume	56
Issue number	12
DOIs	https://doi.org/10.1021/np50102a023
State	Published - Dec 1993

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abstract = "Two new cyclic peroxide-containing polyketide C16 acids 2 and 4 with their methyl esters 3 and 5 have been isolated from the Indo-Pacific marine sponge Plakortis aff. simplex. Both 2 and 3 are proposed to contain a single 1,2-dioxene ring, while 4 and 5 incorporate two 1,2-dioxene rings. The structures were elucidated mainly through 1D and 2D nmr spectral analysis. The methyl esters 3 and 5 were found to be active against cultured P-388 murine leukemia cells.",

author = "Amira Rudi and Ravit Talpir and Yoel Kashman and Yehuda Benayahu and Michael Schleyer",

year = "1993",

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AU - Schleyer, Michael

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Four new C₁₆ 1,2-dioxene-polyketides from the sponge plakortis aff. Simplex

Abstract

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