Four new C16 1,2-dioxene-polyketides from the sponge plakortis aff. Simplex

Amira Rudi, Ravit Talpir, Yoel Kashman, Yehuda Benayahu, Michael Schleyer

Research output: Contribution to journalArticlepeer-review

Abstract

Two new cyclic peroxide-containing polyketide C16 acids 2 and 4 with their methyl esters 3 and 5 have been isolated from the Indo-Pacific marine sponge Plakortis aff. simplex. Both 2 and 3 are proposed to contain a single 1,2-dioxene ring, while 4 and 5 incorporate two 1,2-dioxene rings. The structures were elucidated mainly through 1D and 2D nmr spectral analysis. The methyl esters 3 and 5 were found to be active against cultured P-388 murine leukemia cells.

Original languageEnglish
Pages (from-to)2178-2182
Number of pages5
JournalJournal of Natural Products
Volume56
Issue number12
DOIs
StatePublished - Dec 1993

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