Foscarnet-related Hypercalcemia during CMV Treatment in an Infant with SCID: A Case Report and Review of Literature

Shira Rabinowicz; Raz Somech; Yonatan Yeshayahu

doi:10.1097/MPH.0000000000000682

Foscarnet-related Hypercalcemia during CMV Treatment in an Infant with SCID: A Case Report and Review of Literature

Shira Rabinowicz, Raz Somech, Yonatan Yeshayahu^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Foscarnet is a main treatment for disseminated cytomegalovirus infection in immunocompromised patients. One of its documented side effects is hypocalcemia. Hypercalcemia, in contrast, was described anecdotally before, almost exclusively in adults with human immunodeficiency virus infection or posttransplantation. We describe a case of severe hypercalcemia during foscarnet treatment in an infant with IL-7 Rα deficient severe combined immunodeficiency, resolved after treatment cessation. We speculate that this unusual side effect is caused by foscarnet binding to the inorganic matrix of bone.

Original language	English
Pages (from-to)	e173-e175
Journal	Journal of Pediatric Hematology/Oncology
Volume	39
Issue number	3
DOIs	https://doi.org/10.1097/MPH.0000000000000682
State	Published - 2017

Keywords

CMV
SCID
foscarnet
hypercalcemia

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/MPH.0000000000000682

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abstract = "Foscarnet is a main treatment for disseminated cytomegalovirus infection in immunocompromised patients. One of its documented side effects is hypocalcemia. Hypercalcemia, in contrast, was described anecdotally before, almost exclusively in adults with human immunodeficiency virus infection or posttransplantation. We describe a case of severe hypercalcemia during foscarnet treatment in an infant with IL-7 Rα deficient severe combined immunodeficiency, resolved after treatment cessation. We speculate that this unusual side effect is caused by foscarnet binding to the inorganic matrix of bone.",

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AB - Foscarnet is a main treatment for disseminated cytomegalovirus infection in immunocompromised patients. One of its documented side effects is hypocalcemia. Hypercalcemia, in contrast, was described anecdotally before, almost exclusively in adults with human immunodeficiency virus infection or posttransplantation. We describe a case of severe hypercalcemia during foscarnet treatment in an infant with IL-7 Rα deficient severe combined immunodeficiency, resolved after treatment cessation. We speculate that this unusual side effect is caused by foscarnet binding to the inorganic matrix of bone.

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Foscarnet-related Hypercalcemia during CMV Treatment in an Infant with SCID: A Case Report and Review of Literature

Abstract

Keywords

UN SDGs

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