Forty five percent of the Israeli population were infected with the influenza B Victoria virus during the winter season 2015-16

Sivan Sharabi, Ravit Bassal, Nehemya Friedman, Yaron Drori, Hadar Alter, Aharona Glatman-Freedman, Musa Hindiyeh, Daniel Cohen, Ella Mendelson, Tamy Shohat, Michal Mandelboim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

While infection with influenza A viruses has been extensively investigated, infections with influenza B viruses which are commonly categorized into the highly homologous Victoria and Yamagata lineages, are less studied, despite their considerable virulence. Here we used RT-PCR assays, hemagglutination inhibition assays and antibody titers to determine the levels of influenza B infection. We report of high influenza B Victoria virus prevalence in the 2015-16 winter season in Israel, affecting approximately half of the Israeli population. We further show that the Victoria B virus infected individuals of all ages and that it was present in the country throughout the entire winter season. The vaccine however included the inappropriate Yamagata virus. We propose that a quadrivalent vaccine, that includes both Yamagata and Victoria lineages, should be considered for future influenza vaccination.

Original languageEnglish
Pages (from-to)6623-6629
Number of pages7
JournalOncotarget
Volume9
Issue number5
DOIs
StatePublished - 2018

Keywords

  • Influenza B
  • Vaccine
  • Victoria
  • Yamagata

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