Fornix-based trabeculectomy with mitomycin-C

Hanna Levkovitch-verbin, Mordechai Goldenfeld, Shlomo Melamed*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


BACKGROUND AND OBJECTIVE: Mitomycin-C (MMC) has been shown to improve the surgical success of trabeculecromy; however, the advantages of MMC have been evaluated almost entirely as an adjunct to limbal-based trabeculectomy. This study evaluated the efficacy and safety of fornix-based trabeculectomy with MMC for glaucomatous patients. PATIENTS AND METHODS: Between January 1993 and April 1995, 71 patients underwent fornix-based trabeculectomy with topical application of 0.4 mg/ml of MMC for 3 minutes. The conjunctiva- Tenon's capsule flap was spread over the limbus and sutured in order to create a visible crease with a watertight closure. The mean follow-up time was 14.5 months. RESULTS: The mean intraocular pressure (IOP) before surgery was 32.4 ± 9.7 mm Hg. The average postoperative IOP was 14.04 ± 9.57 mm Hg. An IOP of 20 mm Hg or less was observed in 57 eyes (80%). Postoperatively, 37 eyes (52%) required no additional medical therapy. One month after surgery, only 2 patients had wound leakage with hypotony and choroidal detachment. Two eyes (3%) had suprachoroidal hemorrhage with loss of vision. A conjunctival 'buttonhole' occurred in 2 eyes (3%), but only 1 persisted more than a month. CONCLUSIONS: Fornix-based trabeculectomy using intraoperative application of 0.4 mg/ml of MMC for 3 minutes was found to be as safe and effective as limbal-based trabeculectomy with MMC.

Original languageEnglish
Pages (from-to)818-822
Number of pages5
JournalOphthalmic Surgery and Lasers
Issue number10
StatePublished - Oct 1997


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