Formation of Novel Octuplex DNA Molecules from Guanine Quadruplexes

Liat Katrivas, Natalie Fardian-Melamed, Dvir Rotem, Danny Porath, Alexander Kotlyar

Research output: Contribution to journalArticlepeer-review

Abstract

Guanine quadruplex (G4)-DNA structures have sparked the interest of many scientists due to their important biological roles and their potential use in molecular nanoelectronics and nanotechnology. The high guanine content in G4-DNA endows it with mechanical stability, robustness, and improved charge transport properties—attractive attributes for a molecular nanowire. The self-driven formation of a novel G4-DNA-based nanostructure, coined guanine octuplex (G8)-DNA, is reported herein. Atomic force microscopy and scanning tunneling microscopy characterization of this molecule reveal its organized coiled-coil structure, which is found to be stable under different temperatures and surrounding conditions. G8-DNA exhibits enhanced stiffness, mechanical and thermodynamic stability when compared to its parent G4-DNA. These, along with its high guanine content, make G8-DNA a compelling new molecule, and a highly prospective candidate for molecular nanoelectronics.

Original languageEnglish
Article number2006932
JournalAdvanced Materials
Volume33
Issue number8
DOIs
StatePublished - 24 Feb 2021

Keywords

  • DNA nanoelectronics
  • guanine octuplex (G8-DNA)
  • guanine quadruplex (G4-DNA)

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