Formation and characterization of stable human serum albumin-tris-malonic acid [C60]fullerene complex

Bogdan Belgorodsky, Ludmila Fadeev, Varda Ittah, Hadar Benyamini, Stanislav Zelner, Dan Huppert, Alexander B. Kotlyar, Michael Gozin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

The preparation and characterization of the stable human serum albumin (HSA)-C3 isomer of tris-malonic acid [C60]fullerene complex is reported. Other than the anti-fullerene antibody, a stable protein-fullerene complex with a native protein has never been observed. This study may provide valuable answers to the growing concern regarding the effects of carbonaceous nanomaterials on human health on one hand and, on the other, may lead to the development of novel antioxidant therapeutic agents, radiopharmaceuticals, and components for bioelectronic devices.

Original languageEnglish
Pages (from-to)1058-1062
Number of pages5
JournalBioconjugate Chemistry
Volume16
Issue number5
DOIs
StatePublished - 2005

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