Formal Synthesis of the Human Rhinovirus 3C Protease Inhibitor (-)-Thysanone

Sandip V. Mulay; Sachin P. Gholap; Rodney A. Fernandes

doi:10.1002/ajoc.201500070

Formal Synthesis of the Human Rhinovirus 3C Protease Inhibitor (-)-Thysanone

Sandip V. Mulay, Sachin P. Gholap, Rodney A. Fernandes^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A strategy based on Dötz benzannulation and an oxa-Pictet-Spengler reaction toward the formal synthesis of a human rhinovirus (HRV) 3C protease inhibitor, the pyranonaphthoquinone (-)-thysanone, is presented.

Original language	English
Pages (from-to)	560-566
Number of pages	7
Journal	Asian Journal of Organic Chemistry
Volume	4
Issue number	6
DOIs	https://doi.org/10.1002/ajoc.201500070
State	Published - 1 Jun 2015
Externally published	Yes

Keywords

(-)-thysanone
Dötz benzannulation
Human rhinovirus 3C protease
Oxa-Pictet-Spengler reaction
Pyranonaphthoquinones

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10.1002/ajoc.201500070

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title = "Formal Synthesis of the Human Rhinovirus 3C Protease Inhibitor (-)-Thysanone",

abstract = "A strategy based on D{\"o}tz benzannulation and an oxa-Pictet-Spengler reaction toward the formal synthesis of a human rhinovirus (HRV) 3C protease inhibitor, the pyranonaphthoquinone (-)-thysanone, is presented.",

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author = "Mulay, {Sandip V.} and Gholap, {Sachin P.} and Fernandes, {Rodney A.}",

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AU - Gholap, Sachin P.

AU - Fernandes, Rodney A.

PY - 2015/6/1

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KW - Dötz benzannulation

KW - Human rhinovirus 3C protease

KW - Oxa-Pictet-Spengler reaction

KW - Pyranonaphthoquinones

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Formal Synthesis of the Human Rhinovirus 3C Protease Inhibitor (-)-Thysanone

Abstract

Keywords

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