TY - JOUR
T1 - Food-seeking behavior is triggered by skin ultraviolet exposure in males
AU - Parikh, Shivang
AU - Parikh, Roma
AU - Michael, Keren
AU - Bikovski, Lior
AU - Barnabas, Georgina
AU - Mardamshina, Mariya
AU - Hemi, Rina
AU - Manich, Paulee
AU - Goldstein, Nir
AU - Malcov-Brog, Hagar
AU - Ben-Dov, Tom
AU - Glaich, Ohad
AU - Liber, Daphna
AU - Bornstein, Yael
AU - Goltseker, Koral
AU - Ben-Bezalel, Roy
AU - Pavlovsky, Mor
AU - Golan, Tamar
AU - Spitzer, Liron
AU - Matz, Hagit
AU - Gonen, Pinchas
AU - Percik, Ruth
AU - Leibou, Lior
AU - Perluk, Tomer
AU - Ast, Gil
AU - Frand, Jacob
AU - Brenner, Ronen
AU - Ziv, Tamar
AU - Khaled, Mehdi
AU - Ben-Eliyahu, Shamgar
AU - Barak, Segev
AU - Karnieli-Miller, Orit
AU - Levin, Eran
AU - Gepner, Yftach
AU - Weiss, Ram
AU - Pfluger, Paul
AU - Weller, Aron
AU - Levy, Carmit
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/7
Y1 - 2022/7
N2 - Sexual dimorphisms are responsible for profound metabolic differences in health and behavior. Whether males and females react differently to environmental cues, such as solar ultraviolet (UV) exposure, is unknown. Here we show that solar exposure induces food-seeking behavior, food intake, and food-seeking behavior and food intake in men, but not in women, through epidemiological evidence of approximately 3,000 individuals throughout the year. In mice, UVB exposure leads to increased food-seeking behavior, food intake and weight gain, with a sexual dimorphism towards males. In both mice and human males, increased appetite is correlated with elevated levels of circulating ghrelin. Specifically, UVB irradiation leads to p53 transcriptional activation of ghrelin in skin adipocytes, while a conditional p53-knockout in mice abolishes UVB-induced ghrelin expression and food-seeking behavior. In females, estrogen interferes with the p53–chromatin interaction on the ghrelin promoter, thus blocking ghrelin and food-seeking behavior in response to UVB exposure. These results identify the skin as a major mediator of energy homeostasis and may lead to therapeutic opportunities for sex-based treatments of endocrine-related diseases.
AB - Sexual dimorphisms are responsible for profound metabolic differences in health and behavior. Whether males and females react differently to environmental cues, such as solar ultraviolet (UV) exposure, is unknown. Here we show that solar exposure induces food-seeking behavior, food intake, and food-seeking behavior and food intake in men, but not in women, through epidemiological evidence of approximately 3,000 individuals throughout the year. In mice, UVB exposure leads to increased food-seeking behavior, food intake and weight gain, with a sexual dimorphism towards males. In both mice and human males, increased appetite is correlated with elevated levels of circulating ghrelin. Specifically, UVB irradiation leads to p53 transcriptional activation of ghrelin in skin adipocytes, while a conditional p53-knockout in mice abolishes UVB-induced ghrelin expression and food-seeking behavior. In females, estrogen interferes with the p53–chromatin interaction on the ghrelin promoter, thus blocking ghrelin and food-seeking behavior in response to UVB exposure. These results identify the skin as a major mediator of energy homeostasis and may lead to therapeutic opportunities for sex-based treatments of endocrine-related diseases.
UR - http://www.scopus.com/inward/record.url?scp=85133840961&partnerID=8YFLogxK
U2 - 10.1038/s42255-022-00587-9
DO - 10.1038/s42255-022-00587-9
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C2 - 35817855
AN - SCOPUS:85133840961
SN - 2522-5812
VL - 4
SP - 883
EP - 900
JO - Nature Metabolism
JF - Nature Metabolism
IS - 7
ER -
