Food preferences, body weight, and platelet-poor plasma serotonin and catecholamines

I. Blum*, L. Nessiel, E. Graff, A. Harsat, U. Gabbay, J. Sulkes, O. Raz, Y. Vered

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The possible relationship between body weight, food preferences, and plasma neurotransmitters was investigated in 96 healthy volunteers. The volunteers were divided into groups according to sex, body mass index, and food preferences. In all groups fasting platelet-poor plasma (PPP) norepinephrine and serotonin (5-HT) were examined. PPP-5-HT was low in obese individuals (x̄ ± SD: 51.7 ± 34.6 nmol/L) in comparison with lean individuals (94.31 ± 85.2 nmol/L; P < 0.01), in lean male carbohydrate cravers (22.7 ± 16.4 nmol/L) in comparison with protein cravers (132.9 ± 80.6 nmol/L; P < 0.005) and noncravers (64.7 ± 51.7 nmol/L; P < 0.05), and in obese male carbohydrate cravers (34 ± 22.7 nmol/L) in comparison with obese male protein cravers (98.8 ± 28.4 nmol/L; P < 0.001). In conclusion, PPP-5-HT might be seen as a peripheral indicator of processes linked with food consumption and food preferences.

Original languageEnglish
Pages (from-to)486-489
Number of pages4
JournalAmerican Journal of Clinical Nutrition
Issue number4
StatePublished - 1993
Externally publishedYes


  • 3,4- dihydroxyphenylalanine
  • Food preferences
  • body weight
  • dihydroxyphenylacetic acid
  • dopamine
  • plasma norepinephrine
  • plasma serotonin


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