FolM, A New Chromosomally Encoded Dihydrofolate Reductase in Escherichia coli

Moshe Giladi; Neta Altman-Price; Itay Levin; Liat Levy; Moshe Mevarech

doi:10.1128/JB.185.23.7015-7018.2003

FolM, A New Chromosomally Encoded Dihydrofolate Reductase in Escherichia coli

Moshe Giladi, Neta Altman-Price, Itay Levin, Liat Levy, Moshe Mevarech^*

^*Corresponding author for this work

Biotechnology

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Escherichia coli (thyA ΔfolA) mutants are viable and can grow in minimal medium when supplemented with thymidine alone. Here we present evidence from in vivo and in vitro studies that the ydgB gene determines an alternative dihydrofolate reductase that is related to the trypanosomatid pteridine reductases. We propose to rename this gene folM.

Original language	English
Pages (from-to)	7015-7018
Number of pages	4
Journal	Journal of Bacteriology
Volume	185
Issue number	23
DOIs	https://doi.org/10.1128/JB.185.23.7015-7018.2003
State	Published - Dec 2003

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10.1128/JB.185.23.7015-7018.2003

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title = "FolM, A New Chromosomally Encoded Dihydrofolate Reductase in Escherichia coli",

abstract = "Escherichia coli (thyA ΔfolA) mutants are viable and can grow in minimal medium when supplemented with thymidine alone. Here we present evidence from in vivo and in vitro studies that the ydgB gene determines an alternative dihydrofolate reductase that is related to the trypanosomatid pteridine reductases. We propose to rename this gene folM.",

author = "Moshe Giladi and Neta Altman-Price and Itay Levin and Liat Levy and Moshe Mevarech",

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AU - Giladi, Moshe

AU - Altman-Price, Neta

AU - Levin, Itay

AU - Levy, Liat

AU - Mevarech, Moshe

PY - 2003/12

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AB - Escherichia coli (thyA ΔfolA) mutants are viable and can grow in minimal medium when supplemented with thymidine alone. Here we present evidence from in vivo and in vitro studies that the ydgB gene determines an alternative dihydrofolate reductase that is related to the trypanosomatid pteridine reductases. We propose to rename this gene folM.

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FolM, A New Chromosomally Encoded Dihydrofolate Reductase in Escherichia coli

Abstract

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